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But because there arent published human clinical trials on KPV, we simply dont yet know how this translates to humans, what dosing ranges are best, or whether it's safe over the long term

The main safety consideration is ensuring your replacement hormone dose remains adequate as your metabolism and medication absorption may shift during GLP-1 therapy

In addition, because the studies participants had severe hyperglycaemia, metformins glucose-lowering effect may have also been related to changes in peripheral insulin sensitivity, but this was not measured in those studies

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