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The comparison between individuals with schizophrenia and healthy controls indicates that nearly all the medium-chain and long-chain acyl-carnitines were lower in the subject group, which may be caused by the activation or inhibition of different transporters in the plasma membrane

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However, these drugs are very expensive, have not been shown to prevent colectomy in severe ulcerative colitis (Aratari 2008), and may cause autoimmune diseases, cancer, infections, and viral reactivation syndromes including shingles (Colombel 2004)

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