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Initially created to address visceral fat accumulation in specific medical conditions, it has expanded into applications for recovery and body composition management

Biochem Biophys Res Commun 2:17 DOI: 10.1016/0006-291X (60)90252-7 Wood HG, Kellermeyer RW, Stjernholm R, Allen SH (1964) Metabolism of Methylmalonyl-coa and the Role of Biotin and B12 Coenzymes

Positioning in guidelines In the NICE NG28 guideline, 3 the DPP-4 inhibitors may be used first-line when metformin is contraindicated or not tolerated

WAT: white adipose tissue In animal models, high concentrations of free IGF-1 have been shown to inhibit gluconeogenesis, the process by which glucose is produced from non-carbohydrate sources in the liver