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For hTYR, compounds with smaller molecular weights or high flexibility can penetrate the active site with fewer hydrogen bonds and appropriate structures, and more consideration should be given to the potential impact of L2 and L4 (Fig

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doi:10.1016/j.jad.2011.06.005 Farokhnia M, Azarkolah A, Adinehfar F, Khodaie-Ardakani MR, Hosseini SM, Yekehtaz H, Tabrizi M, Rezaei F, Salehi B, Sadeghi SM, Moghadam M, Gharibi F, Mirshafiee O, Akhondzadeh S (2013) N -acetylcysteine as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study