APAP hepatotoxicity occurs through formation of the noxious NAPQI metabolite, which is present in excessive quantities, as augmented by features of glutathione (GSH) depletion, oxidative stress and mitochondrial dysfunction leading to depletion in adenosine triphosphate (ATP) stores
Water, Propanediol, Sodium Ascorbyl Phosphate, Glycerin, Isodecyl Neopentanoate, Squalane, Neopentyl Glycol Diheptanoate, C9-12 Alkane, Sodium Polyacryloyldimethyl Taurate, Ascorbyl Glucoside, Coco-Caprylate/Caprate, Sclerocarya Birrea Seed Oil, Pullulan, Sclerotium Gum, Diglucosyl Gallic Acid, Sorbitan Sesquiisostearate, Glutathione, Sodium Hyaluronate, Sorbeth-30 Tetraisostearate, Dipropylene Glycol, Phloretin, Sodium Citrate, Sodium Metabisulfite, PPG-8-Ceteth-20, Gluconolactone, Acrylates/Beheneth-25 Methacrylate Copolymer, Citric Acid, Tetrasodium Glutamate Diacetate, Silica, Lecithin, Xanthan Gum, Tocopheryl Acetate, Sodium Hydroxide, Phenoxyethanol, Sodium Benzoate, Chondrus Crispus Extract
2 post-infusion
Using a CRISPR-mediated deletion of NADPH-dependent enzyme, Chen et al
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