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This dual hormone mechanism amplifies the metabolic effects: GIP activation appears to work synergistically with GLP-1 receptor activation, producing far greater reductions in body weight and blood sugar levels than GLP-1 alone

Additionally, some discrepancies may be explained by our findings, which show that mRNA co-localization of LepR and GLP-1R varies depending on the anatomical location within the DMH, with a higher overlap percentage in the caudal part of the DMH than the rostral part [69]

To do this, some people adjust the settings on their injection pen to give themselves a smaller dose