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Multidimensional analysis and therapeutic development using patient iPSCderived disease models of Wolfram syndrome

Despite these limitations, the FDA database offers real-world data on clinically relevant adverse events associated with medication use, broadening the pharmacovigilance landscape

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From a mechanistic point of view, metformin can reduce histone acetylation at the CCR8 promoter and inhibit CCR8 expression on tumor-infiltrating Treg cells by upregulating AMPK-activated Sirtuin 2 (SIRT2), thus enhancing the effectiveness of anti-PD-1 immunotherapy (73)