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Proper injection technique with a syringe includes pinching a fold of skin, inserting the needle at a 45-90 degree angle (depending on the needle length and your body composition), injecting slowly, and holding the needle in place for 5-10 seconds after completing the injection to prevent medication from leaking out

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Diabetes 51(6):19381948 Frustaci A, Chimenti C, Setoguchi M, Guerra S, Corsello S, Crea F, Leri A, Kajstura J, Anversa P, Maseri A (1999) Cell death in acromegalic cardiomyopathy

This is why hydration and nutrient support are important during treatment