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doi: 10.1016/j.intimp.2019.105969 28 HelmstdterJKeppelerKAustFKsterLFrenisKFilippouKet al

10.1016/j.arr.2022.101653

Patients with medullary thyroid cancer history, MEN2 syndrome, or certain medication interactions should work with their provider to determine the safest option

Targeting at lipogenesis, pyruvate carboxylase is proven to activate AKT/mTOR pathway, thus upregulating SREBP1c and FASN-induced lipogenesis in TC cells, which promotes anticancer effects [128]