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In this context, inflammatory cytokines and immune cell secretions function as a regulatory valve. In addition to NF-KB and Nrf2/HO-1, the NLRP3 inflammasome and cGAS-STING pathways also play distinctive roles in ferroptosisinflammation crosstalk

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depression, anxiety, mood swings, bouts of anger, memory loss, inability to concentrate, learning disabilities, sleep deprivation, increased risk for heart attacks, strokes, high blood pressure, diabetes, loss of libido, menstrual irregularities, pre-mature menopause, obesity, loss of lean body mass, muscular weakness, and a number of other medical conditions can all arise subsequent to head trauma

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