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In cell-based and animal studies, GHRH-receptor agonism (tesamorelin) and GHS-R1a agonism (ipamorelin) have been reported to engage different intracellular signaling cascades that both terminate in growth-hormone secretion, an arrangement investigators have explored for potentially amplified, rather than simply additive, secretory responses
That does not mean it is irrelevant
This method is often used in surgical planning and research
This has been investigated in 708 T2DM patients, mean age 57 years-old, 66% women, with a mean duration of diabetes of 7 years attending a diabetes conference in several cities in USA
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