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What we are reporting is that the pattern is consistent enough across our patient population to make us think the combination is worth considering in carefully selected cases, while acknowledging that we cannot yet quantify the effect with the rigour that randomized trial evidence would provide

Lipid liquid-liquid phase separation has also been observed in the membranes of the endoplasmic reticulum upon upregulation of the metabolism of saturated fatty acids, which are amenable to high-density packing (Shen et al., 2017)