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For patients who are also exploring surgical options to address stubborn fat, procedures such as liposuction for men or abdominoplasty for men can complement peptide therapy as part of a broader treatment plan

Upper endoscopy or contrast studies may be indicated if anatomical issues such as gastrojejunal anastomosis dilation are suspected, as these may require surgical revision rather than or in addition to pharmacotherapy

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The mainstream copper-biology research community and the broader peptide research community have engaged with the GHK-Cu literature at various points, but the depth of independent characterization outside the Pickart-affiliated research has been variable