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This small molecule compound was developed through sophisticated structure-guided design and binding calculations as part of a systematic effort to create membrane-permeable NNMT inhibitors with enhanced potency and selectivity

Covariates We matched our statistical models for the following covariates: age, sex, T2D complications (kidney, ophthalmic, neurological, and circulatory), comorbidities (alcohol-related disorders, nicotine dependence, hypertension, dyslipidemia, T2D, overweight/obesity, hypertensive disease, cerebrovascular disease, ischemic heart disease, chronic kidney disease, chronic lower respiratory disease, neoplasms, and systemic connective tissue disorders), lipid-lowering agents (HMG-CoA reductase inhibitors, ezetimibe, evolocumab, and alirocumab), antihypertensives (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium-channel blockers, diuretics, and furosemide), anti-anginal or anti-ischemic agents (organic nitrates and ranolazine), heart failure medications (angiotensin receptor-neprilysin inhibitors, eplerenone, vericiguat, digitalis glycosides, SGLT2i, spironolactone, and ivabradine), antiplatelet drugs (aspirin, clopidogrel, ticagrelor, prasugrel, and cangrelor), hemoglobin A1c, and eGFR

Keep a batch in the freezer for easy snacking and enjoy two bites for less than 100 calories