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Complicated dosing rules create friction: you miss a dose because you forgot to set the alarm, or skip it while traveling, and can't guarantee the 30-minute fasting window

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Lixisenatide is also a synthetic version of exendin-4 that has modifications consisting of the deletion of one proline residue and the addition of six lysine residues at the C-terminal end, which increases its half-life and its binding affinity to GLP-1R