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Researchers have also noted that 70% of diabetes patients discontinue GLP-1 receptor agonist treatment within two years, limiting the long-term efficacy of these drugs

In everyday practice, where people eat irregular meals, forget dietary guidelines, and may not titrate doses as carefully, reflux rates of 10 to 15% are commonly reported by prescribers

Gujar SK, Maheshwari S, Bjrkman-Burtscher I, Sundgren PC

Although it was reported that the specificity of the ACPs is better than that of chemotherapy drugs, in some cases, especially in the case of synthetic ACPs, lower specificity toward cancer cells might be observed