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& McClelland, G

Reduced Binding Protein Affinity: In the body, most IGF-1 is bound to a family of proteins known as IGF-binding proteins (IGFBPs)

It has been demonstrated that in sleep deprivation, this system is impaired, promoting an accumulation of neurotoxic residues in areas related to mood disorders, such as the hippocampus, prefrontal cortex, and amygdala [100, 101]