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Description

With regards to neurodegenerative diseases such as AD and PD, the literature has demonstrated the inhibitory effects of GLP-1 on pro-inflammatory cytokines such as TNF-alpha and IL-1betatwo notorious small molecules identified in the microglial-mediated injury observed in said diseases processes

In this case, the regulation of the Se-dependent GSH-Px system by redox changes is lost (see text)

The result is that GI effects that were prominent in week one diminish by week four, even though drug levels are actually higher by week four than week one