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Situations or conditions that can cause vitamin B12 deficiency include: You are more likely to develop vitamin B12 deficiency if you have one or more of the following risk factors: Left untreated, vitamin B12 deficiency can cause lasting side effects that affect your nervous system and brain

doi: 10.1111/j.1476-5829.2012.00343.x

It also indicated directional differences between symptomatic patients and asymptomatic V30M carriers ( p = 0.0297), as well as between asymptomatic V30M carriers and healthy controls ( p = 0.0477