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But the response to any given dose varies substantially based on individual factors
J., Varadharajan, V., Hazen, S
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However, the result of confocal imaging showed that the majority of the administered stapled peptide remains trapped in the lysosomal trafficking pathways, despite the NLS sequence promoting cellular uptake to a certain degree, indicating that endosomal escape continues to be the primary limiting factor affecting proper targeting and the technology of stapled peptides subcellular delivery remain further developed
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