Identification of biological functions of distinct ferroptosis subtypes To clarify the functional differences in different ferroptosis subtypes, we performed GSVA analysis and found that metabolism-related signaling pathway, oxidative phosphorylation, and the TCA cycle were significantly upregulated in Subtype 1, while DNA regulation, chemokine signaling, cytokine receptor interaction, autoimmune diseases, various immune cells pathways such as T cell receptor, B cell receptor, Nod-like receptor, natural killer cells activation, and Toll-like receptor pathway were upregulated in subtype 2(Fig
These cytokines also stimulate the proliferation of vascular smooth muscle cells (VSMCs) and the accumulation of oxidized low-density lipoprotein (LDL) particles, which are then captured by foam cells in vessel walls
Prog Neurobiol 57:563581 Suzuki K, Ikegaya Y, Matsuura S, Kanai Y, Endou H, Matsuki N (2001) Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor, insulin-like growth factor and epidermal growth factor in cultured astrocytes
They help the body handle oxidative stress
