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Here are the most common symptoms: Fatigue: Feeling excessively tired or lethargic, even after a full nights rest

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And that the solution to that ultimately is through whatever mechanism, pharmacological or other, get them to 2,100 or just to make the math more fun, get them to 2,080 from 2,200 or whatever

Furthermore, the mutator phenotype associated with defective MutL activity was suppressed when a non-functional recB allele, derived from ET-37 meningococcal strains, replaced the functional recB allele, suggesting that in MutL-deficient strains, hypermutation mostly arises during post-replicative DNA synthesis associated with the activity of the RecBCD recombination pathway (Colicchio et al., 2006a)