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In this article, the authors showed that uPAR is expressed in senescence cells, both in in vivo and in vitro models (liver fibrosis, pancreatic intraepithelial neoplasia, senescent melanocytes, or lung cancer) correlated to a lack of expression in healthy tissue, except for the bronchial epithelium and a subset of immune cells in which a weak expression of uPAR was detected

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Combined effects vary by genetics, baseline weight, diet, and exercise

Martin AA, Tomas FM, Owens PC, Knowles SE, Ballard FJ, Read LC: IGF-I and its variant, des-(13)IGF-I, enhance growth in rats with reduced renal mass