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Treatment cycles usually last 8-12 weeks with periodic assessment of clinical response

A structure-based assignment of the glutathione activator site without transition-state analogues is much more difficult because of labile GSH interactions 2 that likely depend not only on the presence of the first glutathione moiety but also on conformational changes of the glutathionylated enzyme 3,12,37,44

Wang L, Zheng W, Men Q, Ren X, Song S, Ai C (2024a) Curcumin-loaded polysaccharide microparticles alleviated DSS-induced ulcerative colitis by improving intestinal microecology and regulating MAPK/NF-B/Nrf2/NLRP3 pathways

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