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Dose-dependent cytotoxicity is pronounced, as high concentrations disproportionately reduce cell viability, and even low doses of small NPs (e.g., 18 nm) trigger significant toxicity (Gandamalla et al., 2019

Doubling the next dose after a missed week is not advisable, as it can heighten the risk of adverse side effects

Simple dietary shifts work: Premiere Medical Center found that 50% of patients reported reduced side effects after adjusting their diet, demonstrating that targeted nutrition changes deliver measurable benefits