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The process described above happens when ACSL4 and LPCAT3 dope PUFA (for example, arachidonic acid, AA) into membrane-localized lipids, which must be present in a membrane-bound milieu for PUFA to be lethal following peroxidation (51)

Notably, weight regain was faster in people who had been on GLP-1 medications compared to those who had only undergone lifestyle interventions