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It is important to distinguish between direct causation and indirect effects that may occur as a consequence of the medication's primary actions, particularly its effect on weight loss

Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial