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How This Blind Spot Leads Directly Into the Next Crisis If we cannot explain how GLP-1 agonists exert their multi-system effects, then we cannot reliably determine who benefits from them, why certain responses emerge, or which biological signatures distinguish durable responders from partial responders, early plateauers, non-responders, or individuals at risk for muscle loss, inflammatory rebound, or neuroprotective divergence

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6.2 Future prospect Although curcumin has demonstrated potential neuroprotective effects, it is important to highlight that the clinical transformation still encounters numerous challenges and requires further investigation: (1) Most curcumin formulations used in current studies are complex mixtures primarily consisting of curcumin, demethoxycurcumin and bisdemethoxycurcumin

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