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Patients with structural heart disease (valvular abnormalities, cardiomyopathy, congenital defects) or a history of sustained arrhythmias should have cardiology clearance and repeat ECG at 46 weeks after starting therapy

43,44 The two SURMOUNT studies provide valuable comparisons since they share a similar duration and involve participant populations that are comparable, with the primary distinction being the presence or absence of T2D among participants