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GLP-1 acts on the GLP-1R, activating multiple intracellular signaling pathways, including the cAMP/PKA pathway, the PI3K/Akt signaling pathway, and pathways related to anti-inflammatory and anti-oxidative stress responses, among others

Conclusions GLP-1RA medications have progressed beyond another tool for clinicians to manage type 2 diabetes, overweight, and obesity to therapies with robust cardiovascular outcomes

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By favoring GIP receptor potency, tirzepatide can fully engage the GIP pathway while keeping side effects more manageable