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Search Strategy and Selection Criteria Data for this Review were identified by searches of MEDLINE, Current Contents, PubMed, and references from relevant articles using the search terms GLP-1, cardiovascular, neurological, endocrine and cancer

That means: One dose stays active in the system for nearly a full week Levels gradually build over time Full effects typically take 34 weeks to stabilize This is why research protocols are structured around once-weekly dosing