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For a medication to reach NHS patients, it needs to clear three stages: MHRA marketing authorisation

It usually means the opposite of what a gym-goer wants it to mean: the seller is distancing themselves from human use because the product is not approved as a medicine or supplement

Current UK regulatory position includes: Warnings and precautions regarding thyroid C-cell tumours based on animal data, with acknowledgement that human relevance is uncertain Advice regarding pancreatitis risk, with recommendations to discontinue if acute pancreatitis is suspected and not to restart if confirmed No restrictions based on general cancer risk, as human evidence does not support an increased overall malignancy risk Monitoring for gallbladder disease, which has been associated with GLP-1 receptor agonist use The Summary of Product Characteristics (SmPC) for each GLP-1 medicine includes detailed safety information that healthcare professionals should review before prescribing

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