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To address any uncertainty surrounding whether patients had collected and then taken their prescribed medication, which is a major limitation of prescription data, we conducted a more stringent sensitivity analysis in subgroups of patients who had at least two prescriptions for their GLP-1 RA in the baseline period, suggesting that they had used their first prescription

Evaluation of phosphorus and non-phosphorus neutral oligonucleotide backbones for enhancing therapeutic index of gapmer antisense oligonucleotides

The results indicated minimal off-target effect, consistent with previous reports of pDNA-mediated genome editing using this sgRNA 20