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Since these two pathways were previously identified as crucial in the AD-related pathway-gene network, we performed cluster analysis on the union of DEGs from all four groups involved in either Neuroactive ligand-receptor interaction or Calcium signaling pathway

Moreover, this neurochemical imbalance, as hypothesised, was also related to a measure of habitual responding versus goal-directed control over behaviour in these regions, relevant to theories proposing that this bias underlies compulsive behaviour in clinical disorders of obsessive-compulsive disorder and drug addiction 3,32