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The transdermal composition of claim 2 wherein polymer is selected from one or more of polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly (Butyl methacrylate, methyl methacrylate), cellulose polymers (carboxymethylcellulose, ethyl cellulose, hydroxypropylmethylcellulose hydroxypropylcellulose), polyvinylpyrrolidone, polymer of acrylic acid crosslinked with allyl ethers of polyalcohols (carbomer / carbopol)

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Using a panel of 13 ALL cell lines (6 B-cell precursors and 7 T-cell ALL precursors) and untargeted hydrogen nuclear magnetic resonance ( 1 H-NMR)-based metabolomics, we characterized MTX-triggered metabolic disturbance in detail