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It mediates mitophagy, which provides cytoprotective effects by reducing apoptosis and ROS production during renal injury ( 3.2.2 PPAR/PGC-1 PPAR is a ligand-activated nuclear transcription factor that is highly expressed in proximal renal tubules

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However, some smaller molecules like retinoids and Vitamin C can penetrate deep into the live cells of the spinous layer, helping to stimulate cell turnover and providing antioxidant support