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Description

Adults 2.4 mcg

157 SajikumarS.LiQ.AbrahamW

This bone loss does not respond to calcium supplementation alone and is not fully explained by vitamin D deficiency

Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)