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Numerous oral peptide programs failed not because efficacy could not be demonstrated in some patients under some conditions, but because variability precluded regulatory acceptance

The STEP clinical trials of semaglutide showed average weight reductions of roughly 12 to 15 percent of starting body weight over 68 weeks, while the SURMOUNT trials of tirzepatide showed slightly greater average weight loss, with reductions of roughly 18 to 22 percent of starting body weight at the highest doses