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Introduction The coronavirus disease 2019 (COVID-19) pandemic affected more than 602.8 million cases with more than 6.4 million deaths reported globally (The New York Times, 2022)

By integrating multilayered datasets from transcriptomics, proteomics, metabolomics, and CRISPR screens, ML approaches can construct predictive models of proteostasis dynamics, allowing researchers to visualize how stress propagates through cellular networks

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Fourth, samples were dissolved with 75 L 2-chlorobenzalanine (4 ppm)-80% methanol solution and supernatant were filtered (by 0.22-m membrane) to obtain LC-MS samples