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Where miR-101 knockdown in the hippocampus of C57BL/6 J mice showed AMPK hyperphosphorylation, upregulation of miR-101 target genes associated with AD such as APP , and Rab5 and overproduction of A42 levels (Barbato et al., 2020)

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In neonates and infants, rates of glucuronidation are less than in adults, with a compensatory increase in rates of sulfation.6 There are considerable differences in the maturation of CYP enzyme function depending on the isoenzyme species of interest