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Most good candidates have a BMI (body mass index) of 30 or greater with no serious weight-related conditions, but candidates with a BMI of 27 or more may also benefit from treatment if they have a weight-related condition

A prespecified analysis found the kidney effect to be directionally consistent regardless of baseline SGLT2i use, with no significant treatment-by-subgroup interaction, although only a small minority of participants were taking an SGLT2i at entry, so the combination subgroup was underpowered and does not by itself establish additive benefit

Real support.

This suggests that the effect of glucagon on somatostatin secretion is not indirectly mediated via insulin (neither glucagon-stimulated insulin secretion nor any other acutely stimulated insulin secretion)