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Historically, peptides were first isolated in the early 20th century, with insulin being one of the most notable discovered in 1921 and later synthesized as a treatment for diabetes

Plant Physiol Biochem 49:12281237 Soltesz A, Timar I, Vashegyi I, Toth B, Kellos T, Szalai G, Vagujfalvi A, Kocsy G, Galiba G (2011) Redox changes during cold acclimation affect freezing tolerance but not the vegetative/reproductive transition of the shoot apex in wheat

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