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This inflammatory milieu, characterized by elevated levels of cytokines such as IL-6 and CRP, provides continuous activation signals to macrophages ( 3

It is interesting to note that other post-acute infection syndromes (PAIS) and some neuropsychiatric diseases such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), depression (especially the atypical/immunometabolic subtype (IMD) [86]) and others also have fatigue as a leading clinical symptom, which may serve as a model for investigating the mechanisms of fatigue and drawing conclusions regarding therapeutic options in long COVID

C., Ibi, A., Wood, S., Hardy, M., Gahler, R