Notably, PG-102 showed the lowest CD45 area among groups, suggesting a possible trend toward reduced local inflammation compared to semaglutide or tirzepatide (Supplementary Fig
Potential serious side effects of Mounjaro include: Pancreatitis (inflammation of the pancreas) Increased risk of thyroid cancer (thyroid tumors) Kidney problems, such as acute kidney injury Changes in vision Acute gallbladder problems Serious allergic reactions such as anaphylaxis Hypoglycemia, or low blood sugar Anyone taking Mounjaro who starts to experience signs of low blood sugar should immediately be given fast-acting carbohydrates, like juice or candy
The rapid onset of nasal delivery, with peak levels at approximately 8 minutes, means the peptide reaches relevant brain and peripheral receptors by the time eating begins
Additionally, I would like to see further preclinical and prospective studies that could explain or validate the association between GLP-1 usage and reduced rates of pulmonary embolism, as this stood out as a huge potential benefit in patients with cancer. For more information: Aditya Mahadevan, MD, can be reached at [email protected]
