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Toxicol Appl Pharmacol 330:7483 Funes HA, Apostolova N, Alegre F, Blas-Garcia A, Alvarez A, Marti-Cabrera M, Esplugues JV (2014) Neuronal bioenergetics and acute mitochondrial dysfunction: a clue to understanding the central nervous system side effects of Efavirenz

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Incretins, the current standard of care for obesity, have drawbacks including GI-side effects, rebound after cessation of treatment, and lean mass loss (140, 159, 160)