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According to the new WHO classification of G6PD variants in 2022, it is recommended that the percent activity value should be calculated from the genotypically normal male median (NMM) value, not from the AMM value, considering the overlap of most variants across the 10% threshold [5]

Tumors have evolved a unique microenvironment, and typically display a more acidic condition, hypoxia, overexpressed reactive oxygen species (ROS), and glutathione (GSH) owing to their rapid proliferation and metabolism (Mura et al., 2013