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Cell Reports (2019) 8

Quick Answer: When semaglutide gets warm beyond recommended storage temperatures, the peptide structure denatures, reducing medication potency and therapeutic effectiveness without necessarily causing visible changes

In additional studies, Sekhars group found that deficient mitochondrial fat metabolism was linked to glutathione deficiency, and that correcting glutathione deficiency also improved mitochondrial fuel burning function in aging, as published in the Aging Cell