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Most weight loss isn't limited by hepatic lipid export

Diabetes Obes Metab (2014) 16(9):85060

Once synthesized in by the ribosomes in the rough endoplasmic reticulum (RER), GLP-1R gets targeted to the smooth endoplasmic reticulum (SER) by a signal peptide located at the N-terminus of the receptor [29]

These effects accumulate in brain tissue and persist longer than the compound remains in the bloodstream: A single dose's effects on synaptic density, VEGF signalling, and neuroprotective cascades may last for hours or days after blood levels have dropped to zero Repeated dosing likely leads to cumulative effectseach dose "adds to" the previous dose's neurobiological changes Anecdotal reports of sustained effects after discontinuation (weeks to months in some cases) are consistent with persistent brain changes rather than active drug presence Implications for Dosing This is a crucial point: the observation that effects outlast blood concentrations explains why some community members report benefits from periodic (not daily) dosing and why cycling protocols exist