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Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

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Understanding how these dimers work, including how the signaling of each protomer is modified and how they affect different pathways and systems, is an area that should be enthusiastically studied by those interested in the development of novel pharmacological treatments

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