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Low glutathione and fatigue often goes hand-in-hand with poor mitochondrial function and is often overlooked as well

p = 0.02 for superiority, not prespecified) [30]

Activation of the TMAO-induced endothelial NLRP3 inflammasome was reduced by a mitochondrial ROS scavenger or SIRT3 overexpression in human umbilical vein endothelial cells (HUVECs), which suggested that the activation was mediated in part by inhibition of the SIRT3-SOD2-mtROS signaling pathway (Zhou et al., 2010